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KMID : 0358420150580020144
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Korean Journal of Obstetrics and Gynecology
2015 Volume.58 No. 2 p.144 ~ p.149
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Decreased bone mineral density is associated with coronary atherosclerosis in healthy postmenopausal women
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Seo Seok-Kyo
Yun Bo-Hyon
Noe Eun-Bee
Suh Jong-Wook
Choi Young-Sik
Lee Byung-Seok
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Abstract
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Objective: This study aimed to assess the association between bone mineral density (BMD) and coronary atherosclerosis in healthy postmenopausal women.
Methods: We performed a retrospective review of 252 postmenopausal women who had visited a health promotion center for a routine checkup. BMD of the lumbar spine (L1-L4) and femoral neck was evaluated using dual-energy X-ray absorptiometry, and coronary atherosclerosis was assessed using 64-row multidetector computed tomography. Participants were divided into normal BMD and osteopenia-osteoporosis groups, according to the T-scores of their lumbar spine or femoral neck.
Results: Participants with osteopenia-osteoporosis had a significantly higher proportion of coronary atherosclerosis than did those with normal BMD at the lumbar spine (P=0.003) and femoral neck (P=0.004). Osteopenia-osteoporosis at the lumbar spine (odds ratio [OR], 2.86; 95% confidence interval [CI], 1.12 to 7.27) or femoral neck (OR, 3.35; 95% CI, 1.07 to 10.57) was associated with coronary atherosclerosis, after controlling for age and cardiovascular risk factors.
Conclusion: Decreased BMD is associated with coronary atherosclerosis in healthy postmenopausal women, independent of age and cardiovascular risk factors. Postmenopausal women with decreased BMD may have a higher risk of developing coronary atherosclerosis.
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KEYWORD
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Bone density, Coronary artery disease, Menopause
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